Comparison the Efficiency of Morphine, Propofol and Fentanyl for Controlling Acute Renal Colic in patients admitted to hospital: A Randomized Double-Blind Clinical Trial
Seyed Ashkan Tabibzadeh Dezfuli, Reza Yazdani, Mohsen Esmaeili, Shabnam Kazemi, Saeed Hayati
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ABSTRACT
Background:
Acute
renal colic (ARC) is known as a widespread urological emergency that its
prevalence commonly increases in relation to kidney stone disease. The
different agents are commonly used for relieving
pain. This study, for first time, compared effect of propofol and fentanyl in controlling ARC of patients admitted to the
Shahid Mohammadi Hospital (Bandar Abbas-Iran).
Methods: A total of 150 eligible patients were
randomly selected from patients referred toShahidMohammadi hospital, Bandar
Abbas. The basal pain values of the patients were investigated by the Visual
Analogue Scale (VAS) in values from 0 up to 10 at the 0th, (immediately before
drug administration), 15th, and 30th minutes. Value of zero means lack of pain
and 10 means the most pain. Demographic characteristics were also recorded.
Results:
The
results showed that most patients studies were male and middle age. Our
findings did not show significant difference between groups for VAS0 (P>0.05).
The results showed that mean for VAS0 was 8.80, 2.42, 5.05 and 9.01 for
Morphine, Fentanyl and Propofol groups and total, respectively. There was significant difference between
Morphine with Propofol and Fentanyl for VAS30 (P<0.05). The results
showed that values for VAS30 were 2.85, 1.19 and 3.52 for Morphine, Fentanyl
and Propofol groups, respectively.
Conclusion:
Thus,
fentanyl had the best response for controlling pain in patients with ARC. It
can be suggested to use fentanyl for controlling ARC in emergency department
instead of morphine and other conventional agents with higher side effects.
Keywords:
Acute
renal colic, Fentanyl, Morphine, Propofol
ABSTRACT
Background:
Acute
renal colic (ARC) is known as a widespread urological emergency that its
prevalence commonly increases in relation to kidney stone disease. The
different agents are commonly used for relieving
pain. This study, for first time, compared effect of propofol and fentanyl in controlling ARC of patients admitted to the
Shahid Mohammadi Hospital (Bandar Abbas-Iran).
Methods: A total of 150 eligible patients were
randomly selected from patients referred toShahidMohammadi hospital, Bandar
Abbas. The basal pain values of the patients were investigated by the Visual
Analogue Scale (VAS) in values from 0 up to 10 at the 0th, (immediately before
drug administration), 15th, and 30th minutes. Value of zero means lack of pain
and 10 means the most pain. Demographic characteristics were also recorded.
Results:
The
results showed that most patients studies were male and middle age. Our
findings did not show significant difference between groups for VAS0 (P>0.05).
The results showed that mean for VAS0 was 8.80, 2.42, 5.05 and 9.01 for
Morphine, Fentanyl and Propofol groups and total, respectively. There was significant difference between
Morphine with Propofol and Fentanyl for VAS30 (P<0.05). The results
showed that values for VAS30 were 2.85, 1.19 and 3.52 for Morphine, Fentanyl
and Propofol groups, respectively.
Conclusion:
Thus,
fentanyl had the best response for controlling pain in patients with ARC. It
can be suggested to use fentanyl for controlling ARC in emergency department
instead of morphine and other conventional agents with higher side effects.
Keywords:
Acute
renal colic, Fentanyl, Morphine, Propofol