Determine the Relationship Between Proton Pump Inhibitors And Iron Deficiency Anemia
Mehreen Khan, Siraj-Ud-Din, Arif Mumtaz, Muhammad Atif Tauseef, Muhammad Ayaz, Umair Ul Islam
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ABSTRACT
Aim: To examine the relationship between iron
deficiency anemia and patients with proton pump inhibitors therapy.
Study design: Retrospective/observational
Place and
Duration of Study: Medical OPD DHQ Kohat and Medical Unit from 1st
January 2018 to 31st August 2018.
Methods: Total 100 patients of
both genders with ages 20 to 65 years presented with gastrointestinal diseases
and advised to use proton pump inhibitors therapy were enrolled in this study.
Patients detailed demographic including age, sex and residence were recorded
after taking informed written consent. Serum ferritin level and iron level were
examined at start and at 8 months of PPI therapy.
Results: Fifty eight (58%)
patients were males while 42 (42%) were females with mean age 40.25±11.66
years. Majority of patients 59 (59%) had urban residency. At start of treatment
mean serum ferritin level was 67.85±32.52ng/ml and at 8 months it was
26.54±14.62ng/ml, a significant difference was observed with p-value <0.001.
Mean iron level at start of treatment was 19.34±5.45umol/l and at 8 months it
was 16.5±4.66 µmol/l. Iron deficiency anemia was found in 26 (26%) patients at
8 months follow-up
Conclusion: There was strong relationship
between iron deficiency anemia and proton pump inhibitor therapy.