Mehreen Khan, Siraj-Ud-Din, Arif Mumtaz, Muhammad Atif Tauseef, Muhammad Ayaz, Umair Ul Islam

Determine the Relationship Between Proton Pump Inhibitors And Iron Deficiency Anemia

Mehreen Khan, Siraj-Ud-Din, Arif Mumtaz, Muhammad Atif Tauseef, Muhammad Ayaz, Umair Ul Islam



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ABSTRACT

 

Aim: To examine the relationship between iron deficiency anemia and patients with proton pump inhibitors therapy.

Study design: Retrospective/observational

Place and Duration of Study: Medical OPD DHQ Kohat and Medical Unit from 1st January 2018 to 31st August 2018.

Methods: Total 100 patients of both genders with ages 20 to 65 years presented with gastrointestinal diseases and advised to use proton pump inhibitors therapy were enrolled in this study. Patients detailed demographic including age, sex and residence were recorded after taking informed written consent. Serum ferritin level and iron level were examined at start and at 8 months of PPI therapy.

Results: Fifty eight (58%) patients were males while 42 (42%) were females with mean age 40.25±11.66 years. Majority of patients 59 (59%) had urban residency. At start of treatment mean serum ferritin level was 67.85±32.52ng/ml and at 8 months it was 26.54±14.62ng/ml, a significant difference was observed with p-value <0.001. Mean iron level at start of treatment was 19.34±5.45umol/l and at 8 months it was 16.5±4.66 µmol/l. Iron deficiency anemia was found in 26 (26%) patients at 8 months follow-up

Conclusion: There was strong relationship between iron deficiency anemia and proton pump inhibitor therapy.

Keywords: Gastrointestinal disease, Serum ferritin level, Proton pump inhibitors, Anemia


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