Examine the Prevalence of H. Pylori Infection Also Determine the Accuracy of Rapid Urease Test and Histopathology Examination for Diagnosing H. Pylori Infection
M. Rizwan Hafeez, Sibgha Bashir, Jalil Iqbal, Adeel Zafar, Faghia Shahid, Rabia Saeed
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ABSTRACT
]
Aim: To examine the accuracy of RUT and compare
with histopathology examination to diagnose H. pylori infection in patients
presented with gastritis
Study design: Prospective/Observational study
Place & duration: Department
of Pathology Shahida Islam Medical College Lodhran from 1st March
2016 to 31st January 2017
Methods: A total 120 patients of both genders with
ages 20 to 70 years having gastritis were included in this study. Four biopsies
were taken from all the patients 2 biopsies were taken for the RUT and 2 for
the histopathology examination. Sensitivity, specificity, PPV and NPV were
examined of both methods.
Results: Out of 120 patients 57 (47.5%) patients were
males while 52.5% patients were females. 80 (66.67%) patients had H.pylori
infection by Rapid urease test and 79 (65.83%) patients had H pylori infection
as per histopathology examination. Association between RUT and Histopathology
examination were noted as sensitivity, specificity, PPV and NPV as 96.20%,
92.5%, 95% and 90.24% respectively.
Conclusion: It is concluded from this study that rapid
urease test shows accurate results with no procedural complications. It is a
good alternative to histopathology examination in patients presented with
gastritis.
Keyword:
Rapid urease test, Histopathology, H. Pylori
ABSTRACT
]
Aim: To examine the accuracy of RUT and compare
with histopathology examination to diagnose H. pylori infection in patients
presented with gastritis
Study design: Prospective/Observational study
Place & duration: Department
of Pathology Shahida Islam Medical College Lodhran from 1st March
2016 to 31st January 2017
Methods: A total 120 patients of both genders with
ages 20 to 70 years having gastritis were included in this study. Four biopsies
were taken from all the patients 2 biopsies were taken for the RUT and 2 for
the histopathology examination. Sensitivity, specificity, PPV and NPV were
examined of both methods.
Results: Out of 120 patients 57 (47.5%) patients were
males while 52.5% patients were females. 80 (66.67%) patients had H.pylori
infection by Rapid urease test and 79 (65.83%) patients had H pylori infection
as per histopathology examination. Association between RUT and Histopathology
examination were noted as sensitivity, specificity, PPV and NPV as 96.20%,
92.5%, 95% and 90.24% respectively.
Conclusion: It is concluded from this study that rapid
urease test shows accurate results with no procedural complications. It is a
good alternative to histopathology examination in patients presented with
gastritis.