ABSTRACT

Aim: To determine the level of vitamin D in patients with tuberculosis and compare it without tuberculosis patients.

Study design: Cross-sectional/Observational

Place and duration of study: Department of Medicine, AkhtarSaeed Medical and Dental College, Lahore from 1^st April 2019 30^th September 2019.

Methods: Seventy patients of both genders presented with pulmonary tuberculosis with ages 20 to 70 years and 70 patients non tuberculosis with same age range were enrolled in this study. Sputum examination by gene Xpert method was used to examine the tuberculosis. Blood sample was takenfrom all the patients to examine the vitamin D level. Serum hydroxyl vitamin D 25 level less than 25ng/ml was considered as deficiency of vitamin D. Data was analyzed by SPSS 24.0.

Results: There were 46 (65.71%) male and 24 (34.29%) females in group I and 42(60%) males and 28 (40%) females in group II. Mean age of patients in group I was 36.42±12.85 years and in group II it was 35.96±13.24 years. Vitamin D level was significantly low in tuberculosis patients as compared to healthy patients (22.79±5.14ng/ml Vs 31.76±9.52ng/ml) with p-value <0.0001. In group I 55 (78.57%) and in group II 18 (25.71%) patients had vitamin D deficiency, a significant difference between both groups (P-value <0.001).

Conclusion: It is concluded that vitamin D deficiency is highly associated with pulmonary tuberculosis patients.