Examine the Association of Proton Pump Inhibitors with Iron Deficiency Anemia
Muhammad Rizwan Hafeez, Sibgha Bashir, Umair Arif, Adil Mehmood, Rana Aatif Siddique, Anas Ahmed Qureshi
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ABSTRACT
Aim: To
determine the association of iron deficiency anemia in patients with proton
pump inhibitors therapy.
Study design: Retrospective/observational
study
Place & duration: Department
of Medicine, Shahida Islam Medical College Lodhran from 1stJuly 2018
to 31st December 2019.
Methods: One hundred and fifty patients of both
genders with ages 20 to 70 years presented with gastrointestinal diseases and
advised to use proton pump inhibitors therapy were enrolled in this study.
Patients detailed demographic including age, sex and residence were recorded
after taking informed written consent. Serum ferritin level and iron level were
examined at the beginning and at 8 months of PPI therapy.
Results:Eighty six (57.33) patients were males while
64(42.67%) were females with mean age 42.15±12.38 years. Majority of patients
90(60%) had urban residency. At beginning of treatment mean serum ferritin
level was 68.72±30.41ng/ml and at 8 months it was 27.45±16.26ng/ml, a
significant difference was observed with p-value <0.001. Mean iron level at
start of treatment was 18.28±6.54umol/l and at 8 months it was
15.86±5.72umol/l. Iron deficiency anemia was found in 38(25.33%) patients at 8
months follow-up.
Conclusion: Iron
deficiency anemia is highly associated with proton pump inhibitors therapy. The
frequency of iron deficiency anemia was high at the end of treatment.
Keyword: Gastrointestinal
disease, Proton pump inhibitors, Serum ferritin level, Anemia
ABSTRACT
Aim: To
determine the association of iron deficiency anemia in patients with proton
pump inhibitors therapy.
Study design: Retrospective/observational
study
Place & duration: Department
of Medicine, Shahida Islam Medical College Lodhran from 1stJuly 2018
to 31st December 2019.
Methods: One hundred and fifty patients of both
genders with ages 20 to 70 years presented with gastrointestinal diseases and
advised to use proton pump inhibitors therapy were enrolled in this study.
Patients detailed demographic including age, sex and residence were recorded
after taking informed written consent. Serum ferritin level and iron level were
examined at the beginning and at 8 months of PPI therapy.
Results:Eighty six (57.33) patients were males while
64(42.67%) were females with mean age 42.15±12.38 years. Majority of patients
90(60%) had urban residency. At beginning of treatment mean serum ferritin
level was 68.72±30.41ng/ml and at 8 months it was 27.45±16.26ng/ml, a
significant difference was observed with p-value <0.001. Mean iron level at
start of treatment was 18.28±6.54umol/l and at 8 months it was
15.86±5.72umol/l. Iron deficiency anemia was found in 38(25.33%) patients at 8
months follow-up.
Conclusion: Iron
deficiency anemia is highly associated with proton pump inhibitors therapy. The
frequency of iron deficiency anemia was high at the end of treatment.
Keyword: Gastrointestinal
disease, Proton pump inhibitors, Serum ferritin level, Anemia