Elevated levels of Alanine Transaminase (ALT) is an independent risk factor for Coronary Artery Disease (CAD)
Tanvir Ahmad Bhatti, Syed Muhammad Aftab Hassan, Hamid Khail, Wasim Ashraf, A J Awans, Sadaf Zahra Syyed
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ABSTRACT
Background: Coronary artery disease is the most common
form of heart disease with multifactorial etiology and atherosclerosis. Recently it is considered that ALT
associated with endothelial dysfunction and carotid atherosclerosis. The
predictive value of ALT for
coronary events seems independent of traditional risk factors and the features
of the metabolic syndrome.
Aim: To find out association of
elevated ALT with coronary artery disease
Methods: This
cross sectional study was carried out on 100 patients presented with clinically
suspected CAD. Serum ALT was measured. Patients underwent angiography and
images of coronary arteries were obtained and presence of CAD was noted.
Relative risk was calculated to measure association between raised ALT and CAD.
Results: The
mean age range of patients was 49.16±10.15 years. There were 78 male
and 22 female patients. The male to
female ratio was 3.54:1. The mean ALT was
41.58±16.18U/L. Coronary angiography findings showed that 29% patients had
normal coronaries, 4% had mild CAD, 49% had moderate CAD and 18% had severe
CAD. There were 1.8 times high risk of CAD in patients with raised ALT.
Conclusion: It
is concluded that although difference in CAD and raised ALT is insignificant but the
risk of CAD is 1.8 times high in patients with raised ALT.
Keywords:
Coronary Artery Diseases, Serum Alanine Transaminase
ABSTRACT
Background: Coronary artery disease is the most common
form of heart disease with multifactorial etiology and atherosclerosis. Recently it is considered that
Aim: To find out association of
elevated ALT with coronary artery disease
Methods: This
cross sectional study was carried out on 100 patients presented with clinically
suspected CAD. Serum ALT was measured. Patients underwent angiography and
images of coronary arteries were obtained and presence of CAD was noted.
Relative risk was calculated to measure association between raised ALT and CAD.
Results: The
mean age range of patients was 49.16±10.15 years. There were 78 male
and 22 female patients. The male to
female ratio was 3.54:1. The mean ALT was
41.58±16.18U/L. Coronary angiography findings showed that 29% patients had
normal coronaries, 4% had mild CAD, 49% had moderate CAD and 18% had severe
CAD. There were 1.8 times high risk of CAD in patients with raised ALT.
Conclusion: It
is concluded that although difference in CAD and raised ALT is insignificant but the
risk of CAD is 1.8 times high in patients with raised ALT.
Keywords:
Coronary Artery Diseases, Serum Alanine Transaminase