Faiqa Qurban, Syed Imran-ul-Hassan, Salman Athar Qureshi, Yasmeen Azeem, Abaid-ur-Rehman

Compare the Efficacy of Odansetron versus Prochlorperazine for Preventing Nausea and Vomiting after Laparoscopic Cholecystectomy

Faiqa Qurban, Syed Imran-ul-Hassan, Salman Athar Qureshi, Yasmeen Azeem, Abaid-ur-Rehman



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ABSTRACT

Aim: To compare the efficacy of odansetron with prochlorperazine in preventing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Study Design: Randomized controlled trial

Place and Duration of Study: Main Operation Theatre DHQ Teaching Hospital/Gujranwala Medical College, Gujranwala from 1st January 2019 to 31st October 2019.

Methodology: One hundred and ten patients of both genders with ages 20 to 60 years undergoing laparoscopic cholecystectomy were enrolled in this study. Patients were divided into two groups I and II. Each group contains 55 patients. Group A received odansetron and group B received prochlorperazine before induction of anesthesia. Patients were follower up for postoperative 24 hours to examine the efficacy of medication. Data was analyzed by SPSS 24.0. P-value <0.05 was taken as significant.

Results: No significant difference was observed between both groups regarding age, gender, BMI and ASA class with p-value >0.05. In group A 7 (12.72%) patients had nausea and 10 (18.18%) had vomiting while in group B 8 (14.55%) patients had nausea and 6 (10.91%) patients had vomiting, no significant difference was observed between both groups A and B with p-value >0.05. In group A 8 (14.55%) patients had adverse effects while in group B 12 (21.82%) patients had side effects of medication such as headache, dizziness and sedation. No significant difference was observed regarding anti-emetics use between both groups (p value >0.05).

Conclusion: Ondansetron and prochlorperazine both are safe and effective for preventing postoperative nausea and vomiting with fewer rates of side effects in patients undergoing laparoscopic cholecystectomy.

Keywords: Odansetron, Prochlorperazine, Laparoscopic Surgery, Nausea, Vomiting



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