Compare the Efficacy of Odansetron versus Prochlorperazine for Preventing Nausea and Vomiting after Laparoscopic Cholecystectomy
Faiqa Qurban, Syed Imran-ul-Hassan, Salman Athar Qureshi, Yasmeen Azeem, Abaid-ur-Rehman
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ABSTRACT
Aim: To compare the efficacy of odansetron with prochlorperazine in
preventing postoperative nausea and vomiting in patients undergoing
laparoscopic cholecystectomy.
Study Design: Randomized controlled trial
Place and Duration of
Study: Main Operation Theatre DHQ Teaching
Hospital/Gujranwala Medical College, Gujranwala from 1st January
2019 to 31st October 2019.
Methodology:
One hundred and ten patients of both genders
with ages 20 to 60 years undergoing laparoscopic cholecystectomy were enrolled
in this study. Patients were divided into two groups I and II. Each group
contains 55 patients. Group A received odansetron and group B received
prochlorperazine before induction of anesthesia. Patients were follower up for
postoperative 24 hours to examine the efficacy of medication. Data was analyzed
by SPSS 24.0. P-value <0.05 was taken as significant.
Results:
No significant difference was observed
between both groups regarding age, gender, BMI and ASA class with p-value
>0.05. In group A 7 (12.72%) patients had nausea and 10 (18.18%) had
vomiting while in group B 8 (14.55%) patients had nausea and 6 (10.91%)
patients had vomiting, no significant difference was observed between both
groups A and B with p-value >0.05. In group A 8 (14.55%) patients had
adverse effects while in group B 12 (21.82%) patients had side effects of
medication such as headache, dizziness and sedation. No significant difference
was observed regarding anti-emetics use between both groups (p value >0.05).
Conclusion: Ondansetron and prochlorperazine both are safe and effective for
preventing postoperative nausea and vomiting with fewer rates of side effects
in patients undergoing laparoscopic cholecystectomy.
Keywords: Odansetron, Prochlorperazine, Laparoscopic Surgery,
Nausea, Vomiting
ABSTRACT
Aim: To compare the efficacy of odansetron with prochlorperazine in
preventing postoperative nausea and vomiting in patients undergoing
laparoscopic cholecystectomy.
Study Design: Randomized controlled trial
Place and Duration of
Study: Main Operation Theatre DHQ Teaching
Hospital/Gujranwala Medical College, Gujranwala from 1st January
2019 to 31st October 2019.
Methodology:
One hundred and ten patients of both genders
with ages 20 to 60 years undergoing laparoscopic cholecystectomy were enrolled
in this study. Patients were divided into two groups I and II. Each group
contains 55 patients. Group A received odansetron and group B received
prochlorperazine before induction of anesthesia. Patients were follower up for
postoperative 24 hours to examine the efficacy of medication. Data was analyzed
by SPSS 24.0. P-value <0.05 was taken as significant.
Results:
No significant difference was observed
between both groups regarding age, gender, BMI and ASA class with p-value
>0.05. In group A 7 (12.72%) patients had nausea and 10 (18.18%) had
vomiting while in group B 8 (14.55%) patients had nausea and 6 (10.91%)
patients had vomiting, no significant difference was observed between both
groups A and B with p-value >0.05. In group A 8 (14.55%) patients had
adverse effects while in group B 12 (21.82%) patients had side effects of
medication such as headache, dizziness and sedation. No significant difference
was observed regarding anti-emetics use between both groups (p value >0.05).
Conclusion: Ondansetron and prochlorperazine both are safe and effective for
preventing postoperative nausea and vomiting with fewer rates of side effects
in patients undergoing laparoscopic cholecystectomy.
Keywords: Odansetron, Prochlorperazine, Laparoscopic Surgery,
Nausea, Vomiting