A Review of the Available Remedial Procedures for the Treatment of Fatty Liver Disease
Delaram Eskandari, Niloofar Khodabandehloo, Hosein Samadanifard, Amir Ziaee, Alireza Hejrati
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ABSTRACT
Fatty liver disease (FLD), known
as a common cause of chronic liver disease globally, refers to a spectrum
of disease-causing lipid accumulation in the liver. There are two types of FLD,
including Alcoholic Liver Disease (ALD) and Non-Alcoholic Fatty Liver Disease
(NAFLD). The pathological spectra of these two diseases are similar TO a range
of conditions from steatosis to cirrhosis and hepatocellular carcinoma. The
diagnosis of FLD relays highly on clinical suspicion, laboratory tests, or
diagnostic techniques. Despite advancements in understanding the
pathophysiology of FLD, targeted therapies for the disease are still absent.
Abstinence, nutritional support, and medications such as corticosteroids and
pentoxifylline are used for the management of patients with ALD. The treatment
modality for patients with NAFLD is mainly based on weight loss and adjutant
management using specific agents such as Insulin sensitizers and Anti-oxidants
and cytoprotective therapies. The aim of this study is to provide a thorough
review of the current therapies and strategies regarding the management of ALD
and NAFLD.
Keywords: Fatty liver disease, steatosis, alcoholic
liver disease, abstinence, non-alcoholic fatty liver disease
ABSTRACT
Fatty liver disease (FLD), known
as a common cause of chronic liver disease globally, refers to a spectrum
of disease-causing lipid accumulation in the liver. There are two types of FLD,
including Alcoholic Liver Disease (ALD) and Non-Alcoholic Fatty Liver Disease
(NAFLD). The pathological spectra of these two diseases are similar TO a range
of conditions from steatosis to cirrhosis and hepatocellular carcinoma. The
diagnosis of FLD relays highly on clinical suspicion, laboratory tests, or
diagnostic techniques. Despite advancements in understanding the
pathophysiology of FLD, targeted therapies for the disease are still absent.
Abstinence, nutritional support, and medications such as corticosteroids and
pentoxifylline are used for the management of patients with ALD. The treatment
modality for patients with NAFLD is mainly based on weight loss and adjutant
management using specific agents such as Insulin sensitizers and Anti-oxidants
and cytoprotective therapies. The aim of this study is to provide a thorough
review of the current therapies and strategies regarding the management of ALD
and NAFLD.
Keywords: Fatty liver disease, steatosis, alcoholic
liver disease, abstinence, non-alcoholic fatty liver disease