Excess Body Weight and Markers of Systemic Inflammation in Exacerbation of Asthma-COPD overlap
Svetlana Vasilyevna Faletrova, Larisa Vasilyevna Nikiforova, Eduard Sergeevich Belskikh
1102
ABSTRACT
Aim:
To compare the level of markers of systemic inflammation (IL6, IL8, TNFα) in
patients with bronchial asthma-COPD overlap (ACO) with normal and excess body
weight during exacerbation.
Methods:
The study included 71 people, of whom 30 were patients with a combination of
bronchial asthma and COPD (Asthma-COPD Overlap) in the exacerbation phase and
41 conditionally healthy volunteers. All the subjects were divided into
subgroups depending on the body weight index (BMI) and the presence of
abdominal obesity (AO). Blood sampling was carried out on the second day, prior
to the beginning of treatment with systemic glucocorticosteroids. The plasma
concentration of IL6, IL8, TNFα was determined by enzyme immunoassay.
Results:
In group of patients with exacerbation of the ACO (n=30) the level of plasma
markers of system inflammation was higher in comparison with indicators of
control group (n=41) (IL-6 by 9.1 times, p<0.05; IL-8 by 3.2 times, p<0.05;
TNF-α by 1.9 times, p<0.05). Patients with ACO and AO (n=17) showed an
increase in IL6 concentration and TNFα in comparison with ACO group without AO
(n=13) on 37.6% (p<0.05) and 15.9% (p<0.05) respectively. Both excess
body weightand AO was associated with an increase in plasma concentration of
IL-6 and TNF-α in patients with ACO compared to the group of ACO with normal
body weightper 37.6% and 14.3%, respectively (p<0.05).
Conclusion:
Overweight in patients with exacerbation of ACO is associated with an increase
in the level of IL-6 and TNF-α.
Keywords: Asthma-COPD overlap,
IL-6, TNF- α, overweight.
ABSTRACT
Aim:
To compare the level of markers of systemic inflammation (IL6, IL8, TNFα) in
patients with bronchial asthma-COPD overlap (ACO) with normal and excess body
weight during exacerbation.
Methods:
The study included 71 people, of whom 30 were patients with a combination of
bronchial asthma and COPD (Asthma-COPD Overlap) in the exacerbation phase and
41 conditionally healthy volunteers. All the subjects were divided into
subgroups depending on the body weight index (BMI) and the presence of
abdominal obesity (AO). Blood sampling was carried out on the second day, prior
to the beginning of treatment with systemic glucocorticosteroids. The plasma
concentration of IL6, IL8, TNFα was determined by enzyme immunoassay.
Results:
In group of patients with exacerbation of the ACO (n=30) the level of plasma
markers of system inflammation was higher in comparison with indicators of
control group (n=41) (IL-6 by 9.1 times, p<0.05; IL-8 by 3.2 times, p<0.05;
TNF-α by 1.9 times, p<0.05). Patients with ACO and AO (n=17) showed an
increase in IL6 concentration and TNFα in comparison with ACO group without AO
(n=13) on 37.6% (p<0.05) and 15.9% (p<0.05) respectively. Both excess
body weightand AO was associated with an increase in plasma concentration of
IL-6 and TNF-α in patients with ACO compared to the group of ACO with normal
body weightper 37.6% and 14.3%, respectively (p<0.05).
Conclusion:
Overweight in patients with exacerbation of ACO is associated with an increase
in the level of IL-6 and TNF-α.
Keywords: Asthma-COPD overlap,
IL-6, TNF- α, overweight.