The Role and the Risk of Serum Vitronectin Level in patients with Diabetic and Non- Diabetic Acute M I
Muthanna I. Al-ezzi, Raghad A. Mohsin, Huda Jaber Waheed
1002
ABSTRACT
Background: Acute
myocardial infarction (AMI) is an atherosclerotic disorder of myocardial
necrosis caused by constriction of blood supply to the heart, leading to
myocardial dysfunction and death of the heart cells.
Vitronectin
(VN) is a regulatory plasma glycoprotein, which adjusts the adhesion processes
of platelets, accumulation and coagulation.
Aim: To
investigate the correlation between serum VN level and acute myocardial
infarction (MI) in the presence and absence of diabetes.
Method: This
study includes 30 patients with acute myocardial infarction which were selected
from Iraqi hospitalized patients in the intensive care unit. Those patients
were subdivided into two groups: group 1 involved 6 (53.3) % patients with
diabetic complications; group 2 involved 14 (46.6) % patients as a non-diabetic
group and 30 as control group. After an overnight fasting, 10ml of venous blood
from all patients and healthy subjects was drawn to investigate the biomarkers
(vitronectin, lipid profile, blood urea) in addition to having the body mass
index (BMI) of all the groups.
Results: The results displayed
significant difference in the level of vitronectin, blood urea, TC, LDL-C and
HDL-C between patients with AMI (diabetic and non-diabetic) compared to control
group, while there was non-significant difference in the level of TG and VLDL-C
in diabetic patients with AMI compared to control group. At the same time,
there was a positive correlation between vitronectin, BMI and TC.
Conclusion: The results of the present study were based on a small population of
patients suffering from acute myocardial infarction. Some of them were
complicated with diabetes. All of them presented a high level of vitronectin
which may have a significant role in the induction of AMI, thus represent as a
pathogenic factor for atherosclerosis. Hence, we recommend the use of this
biomarker as a diagnostic test for AMI, however, more studies are needed to
confirm these findings.
Key
words:
acute myocardial infarction, vitronectin, diabetes.
ABSTRACT
Background: Acute
myocardial infarction (AMI) is an atherosclerotic disorder of myocardial
necrosis caused by constriction of blood supply to the heart, leading to
myocardial dysfunction and death of the heart cells.
Vitronectin
(VN) is a regulatory plasma glycoprotein, which adjusts the adhesion processes
of platelets, accumulation and coagulation.
Aim: To
investigate the correlation between serum VN level and acute myocardial
infarction (MI) in the presence and absence of diabetes.
Method: This
study includes 30 patients with acute myocardial infarction which were selected
from Iraqi hospitalized patients in the intensive care unit. Those patients
were subdivided into two groups: group 1 involved 6 (53.3) % patients with
diabetic complications; group 2 involved 14 (46.6) % patients as a non-diabetic
group and 30 as control group. After an overnight fasting, 10ml of venous blood
from all patients and healthy subjects was drawn to investigate the biomarkers
(vitronectin, lipid profile, blood urea) in addition to having the body mass
index (BMI) of all the groups.
Results: The results displayed
significant difference in the level of vitronectin, blood urea, TC, LDL-C and
HDL-C between patients with AMI (diabetic and non-diabetic) compared to control
group, while there was non-significant difference in the level of TG and VLDL-C
in diabetic patients with AMI compared to control group. At the same time,
there was a positive correlation between vitronectin, BMI and TC.
Conclusion: The results of the present study were based on a small population of
patients suffering from acute myocardial infarction. Some of them were
complicated with diabetes. All of them presented a high level of vitronectin
which may have a significant role in the induction of AMI, thus represent as a
pathogenic factor for atherosclerosis. Hence, we recommend the use of this
biomarker as a diagnostic test for AMI, however, more studies are needed to
confirm these findings.
Key
words:
acute myocardial infarction, vitronectin, diabetes.