Abstract

Study objectives: Are to conclude pancytopenia causes, disease severity and presenting symptoms of this illness. Methodology: Mainlycross sectional (descriptive), multicenter and heterogeneous study of seventy patients and on the basis of complete blood count (CBC), patients were admitted with signs symptoms of anemia and pancytopenia in DHQ and Niazi teaching hospitals Sargodha from 01-01-2020 to 30-06-20 (6 months) and were evaluated for the underlying reason. Results: After CBC, peripheral blood film, serum B12, folate, ferritin, iron levels, bone marrow trephine biopsy and examination (where indicated) we foundout of total 70 patients megaloblastic anemia was most prevalent in46 patients,8patients had dimorphic blood picture showing mixed iron and B12 deficiency, hypersplenism in 5 cases, blast cells (leukemias) in 4 patient, 4 patients got aplastic anemia, myelodysplastic syndrome in1 case, multiple myeloma in 1 old aged patient and 1 case of hodgkins lymphoma was also noted. Conclusion: Megaloblastic anemia (B12 and folate deficiencies) are the rapidly correctable causes of pancytopenia in our study followed by mixed deficiency anemia and aplastic anemia. Key words: Pancytopenia, Megaloblastic Anemia, Mixed deficiency anemia