Abstract

Background: Liver disease is a common health problem. Conventional drugs not only cause economic burden but also have many side effects. In medical science herbal remedies have shown beneficial in curing many medical disorders. Berberislycium herbal plant has been used for treating many health related problems. The current study is conducted to observe the hepatoprotective effect of this plant extract on drug induced liver damage.

Objectives: To study the hepatoprotective effects of Berberislycium on Alkaline phosphatase in acetaminophine induced liver damage in mice.

Methods: This experimental study was carried out at Peshawar Medical College Warsak Road Peshawar. Twenty adult Swiss albinomice were selected and divided into four groups with five mice in each group. All groups were made hepatotoxic with acetaminophen 250mg/kg body weightitraperitoneal injection. Group I received acetaminophine only, Group II-IV (E1-E3)were given increasing dose of extract 100mg/kg , 200mg/kg and 400mg/kg body weight respectively. Serum blood samples were taken for Alkaline Phosphatase ALP liver enzyme. Hepatoprotectiveeffect with increasing doses of extract was seen .

Results: ALP Alkaline Phophatase of experimental group Iwas 518±41.2,U/L Alkaline Phophatase levels of experimental groups II-IV were 262±77.8, U/L 184.6±46.8 U/L and 155±34.4.U/L respectively indicating that increasing dose of plant extract lowers Alkaline phophatse levels

Conclusions: Herbal plant Berberis Lycium has shown hepatoprotective effect on liver enzymes and increasing doses of extracts have reduced the level of alkaline phosphatase to normal. This herbal plant can be used as a hepatoprotective agent.

Keywords: Berberis Lyceum, extract, acetaminophine, Alkaline Phosphatse