Abstract

Aim: To determine the frequency of severe vitamin D deficiency and its association with mortality in patients presented with Covid-19.

Study Design: Cross-sectional/Observational

Place and Duration of Study: Chandka Medical College Hospital, Larkana and Gambat Medical College Hospital, Gambat from 1st March 2020 to 31st August 2020

Methodology: One hundred and twenty five patients of both genders diagnosed to have severe covid-19 disease by real time PCR were analyzed. Patient’s ages were ranging from 15 years to 70 years. Detailed demographics were recorded after taking written consent. 5 ml blood sample was taken from all the patients to examine the vitamin D level. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dL). Association between mortality and severe vitamin D deficiency was examined.

Results: Seventy five (60%) were males while 50 (40%) were females with mean age 45.58±15.66 years. Severe vitamin D deficiency was observed in 57 (45.6%) patients. Overall mortality was found in 14 (11.2%) patients, Among 57 patients with severe vitamin D deficiency 12 (9.6%) were died while patients with no vitamin D deficiency 2/68 (1.6%), a significant association was observed between severe vitamin D deficiency and mortality in patients with covid-19 disease with p-value <0.05.

Conclusion: There was strong relationship between severe vitamin-D deficiency and mortality in patients with covid-19 disease.

Keywords: Covid-19, Vitamin D Deficiency, Mortality