Abstract

Objective: - To determine the diagnostic accuracy of Risk of Malignancy Index (RMI) in discrimination of benign from malignant ovarian masses, taking histopathology as gold standard.

Study Design: Cross sectional study.

Place and Duration of Study: Obstetrics and Gynaecology Department of Baqai Medical University, Fatima Hospital, Karachi from 1st January 2019 to 30th June 2019.

Methodology: Two hundred and thirteen women with ultrasound report showing ovarian mass were included in this study. After detailed history and physical examination those suspected of having any ovarian mass was subjected to ultrasound abdomen and pelvis (TVS) and serum CA-125 testing. Scoring for each patient was calculated and malignant and benign was labelled. Surgical specimen was sent to histopathology and report of benign or malignant was recorded.

Results: 29.2% were malignant and using cut-off value of RMI> 200, sensitivity 90.2% and specificity 54.9%, positive predictive value 58.7%, negative predictive value 97.3% and accuracy was 85.9%.

Conclusion: The risk of malignancy index to be a valuable, reliable, and applicable method in the primary evaluation of patients with ovarian masses and a usable method in referral of relevant patients for centralized surgical treatment.

Key Words: Ovarian mass, Risk of malignancy index, CA125