Aloe Vera Gel Accelerates Wound Healing in Oral Mucosa by Promoting Epithelialization and Cell Proliferation (Fibroblasts)
Madiha Rashid, Nedal Iqbal, Adnan Bashir, Ruhina Ali, Saima Rasheed, Sehrish Naz
80
ABSTRACT
Aim: To
evaluate the accelerating effects of Aloe vera gel on the healing process of
tongue wounds.
Study design:
Experimental animal study.
Place and duration of study:
Department of Anatomy, Postgraduate Medical Institute (PGMI), Lahore Pakistan
from 29th April 2021 to 29th October 2021.
Methodology: Forty two albino rats were
divided into one control (group A) and two experimental groups (groups B &
C) with 14 rats in each group. Each group was divided into two sub groups with
7 rats each. Surgical excisional wounds were inflicted on anterior 2/3rd
of dorsal surface of the tongue of each rat on day 1 of the study. The control
group animals were given distilled water while animals in the experimental
groups were given two different doses of Aloe vera gel daily (300 mg/kg and 500
mg/kg).
Results Histological evaluation of the
wounds revealed that epithelialization and fibroblast cell proliferation were
promoted in Aloe vera groups as compared with the control groups. Healing time
was significantly decreased in group B and C animals as compared with group A.
Aloe vera gel accelerated healing in experimental groups.
Conclusion: Aloe vera gel accelerates healing in tongue mucosa
wounds in Wistar rats and it plays its role by bringing enhanced
epithelialzation and fibrosis.
Keywords: Haematoxylin & Eosin
(H&E), Immune Histochemical (IHC), Effect
ABSTRACT
Aim: To
evaluate the accelerating effects of Aloe vera gel on the healing process of
tongue wounds.
Study design:
Experimental animal study.
Methodology: Forty two albino rats were
divided into one control (group A) and two experimental groups (groups B &
C) with 14 rats in each group. Each group was divided into two sub groups with
7 rats each. Surgical excisional wounds were inflicted on anterior 2/3rd
of dorsal surface of the tongue of each rat on day 1 of the study. The control
group animals were given distilled water while animals in the experimental
groups were given two different doses of Aloe vera gel daily (300 mg/kg and 500
mg/kg).
Results Histological evaluation of the
wounds revealed that epithelialization and fibroblast cell proliferation were
promoted in Aloe vera groups as compared with the control groups. Healing time
was significantly decreased in group B and C animals as compared with group A.
Aloe vera gel accelerated healing in experimental groups.
Conclusion: Aloe vera gel accelerates healing in tongue mucosa
wounds in Wistar rats and it plays its role by bringing enhanced
epithelialzation and fibrosis.