Antibiotic resistance has become a significant and growing threat to public and environmental health. The emergence of multiple drug-resistant bacteria has prompted interest in alternatives to conventional antimicrobial. One of the possible replacement options for antibiotics is the use of bacteriophages as antimicrobial. We were forced to look for a new approach in treatment. Phage therapy is an important alternative antibiotic in the current of drug-resistance pathogens. In this way, poisoning bacteria bacteriophage bacteria infect and replicate in bacteria, in this therapy, identify the type of virus per person and can be targeted manipulation of harmful bacteria and then returned the person and invented phage therapy. We discuss the advantages and disadvantages of bacteriophages as therapeutic agents in this regard. And so describe a brief history of bacteriophages and clinical studies on their use in bacterial disease. Much hope is placed in genetic modifications of bacteriophages prevents the development of phage-resistant bacteria.

Keywords: antibiotic resistance‚ bacteriophage, phage therapy