Lead is a highly toxic agent and a potent risk factor for various diseases as its quantity in an environment is increasing day by day.

Aim: To observe and analyze the lead nitrate induced histomorphological changes in the liver of Sprague Dawley rats.

Study Design: Experimental Study.

Methodology: Animals of group A (control) were fed on normal diet but the animals of group B were given 50mg/kg of lead nitrate dissolved in 10ml of distilled water through oral gavage for 14 days daily. SPSS version 22 was used for data analysis. All the quantitative data was expressed as means ± SD. One Way ANOVA followed by Post Hoc Tukey test was applied.

Results: Degenerative effects were noted. The number of Inflammatory and Kupfffer cells is increased with decreased in the body weight. Steatosis and central vein congestion were also present. Conclusion: It was concluded that degenerative effects histologically may be due to oxidative stress produced by formation of free radicals and denaturation of proteins by lead nitrate.

Keywords: Lead, Liver, Central Vein Congestion, Oxidative Stress and Free Radicals.