Emergence of Colistin Resistance against Multi-Drug Resistance Microorganisms and its Clinical Outcomes
Ahmed F. Mady, Basheer Abdel Rahman, Mohammad Al Odat, Waqas Mahmood, Saima Akhtar, Hawra H Albayat, Faisal Alshammary, Anas Mady, Huda Mhawish, Rahaf Felemban, Lamia A Alzaaqi, Batool K Nassan, Waleed Tharwat
2838
ABSTRACT
Background: Over the past
decade, excessive use of Colistin against multidrug-resistant, Gram-negative
bacteria have resulted in the evolution of resistance to Colistin.
Objective: To evaluate
efficacy of Colistin against multidrug-resistant organisms (MDRO), the
emergence of Colistin resistance and its effects on clinical outcomes.
Study Design: Retrospective study
Place and
Duration of Study: King Saud Medical
City (KSMC) from 1st October 2015 till 31st January 2016.
Methodology: Forty-three
patients, resistant to Colistin on blood culture and sensitivity were enrolled.
Results: Colistin was not
effective at breaking the MDRO. The results revealed no significant impact of Colistin
on site of infection such as chest, urinary tract or skin (p=0.612), types of
organisms (p=0.629), length of hospital stay and the IV Colistin days (p=0.097
and p=0.166 respectively) in the past 12 months. The positive finding was that
more than two third (76.7%) of the ICU patients were alive.
Conclusion: Emergence
of Multi drug resistance organism is matter of global concern that caused the
ineffectiveness of many potent antibiotics and led to the drastic clinical
outcomes. Collaboration between medical, paramedical, and administrative staff,
with strict implementation of preventive protocol can slow down the velocity of
microbial multidrug resistance.
Keywords: Multi-drug
resistant, Colistin, Outbreak, Intensive care unit, critically ill patients