Aim: To compare the frequency of hypotension between phenylephrine and ephedrine groups after spinal anesthesia for cesarean delivery.

Study design: Single-blind randomized clinical study

Place and duration of study: Department of Anesthesia, Pain Management and Surgical ICU Civil Hospital, Karachi from 1^st January 2019 to 30^th June 2019.

Methodology: All patients with age between 18 to 35 years having weight range 50kg to70kg with American Society of Anesthesiologist (ASA) physical classification of I and II with Singleton Pregnancy assessed on ultrasound and gestational age 37 to 42 weeks assessed on previous dating scan were enrolled.

Results: The mean age was 26.48±3.05 years, mean weight was 60.07±5.10 Kg, mean height 1.53±0.05m and mean BMI was 27.37±5.01 Kg/m2 respectively. Hypotension was found in 13(17.10%) patients. Comparison of hypotension with pehenylephrine and ephedrine shows that frequency of hypotension was found lower (15.4%) in patients who used pehenylephrine as compared to the patients who used ephiderine (p=0.006).

Conclusion: Significant difference was observed in hypotension between phenylephrine and ephedrine groups after spinal anesthesia for cesarean delivery.

Keywords: Hypotension, cesarean delivery, phenylephrine and ephedrine groups, spinal anesthesia